Yamaguchi University is a national university in Yamaguchi Prefecture, Japan. It has campuses at the cities of Yamaguchi and Ube.
After the Meiji Restoration it became a prefectural secondary school, and in 1894 it developed into (older) Yamaguchi Higher School, a national institute of higher education. It served as a preparatory course for the Imperial University. In February 1905 the school was reorganized into Yamaguchi Higher School of Commerce, the third national commercial college in Japan, after Tokyo (1887) and Kobe (1902). In 1944 the school was renamed Yamaguchi College of Economics.
In 1949 Yamaguchi University was established by integrating six public (national and prefectural) schools in Yamaguchi Prefecture, namely, (Revived) Yamaguchi Higher School, Yamaguchi College of Economics, Ube Technical College, Yamaguchi Normal School, Yamaguchi Youth Normal School and (Prefectural) Yamaguchi College of Veterinary Medicine and Animal Husbandry.
In 1964 Yamaguchi Prefectural Medical College was merged into the university to constitute the School of Medicine. In 1966 Yoshida Campus (the main campus) was opened, and the faculties (except Engineering and Medicine) moved to the campus in the following years.